This
article is based on a study done in the University of Massachusetts. The researchers there studied the process of
mitosis and why it goes wrong at times.
During mitosis the duplicated chromosomes are supposed to divide equally
between two daughter cells. However, in
many cases that does not happen which leads to many problems. The researchers found that in most cases the
problems are due to incorrect interactions between chromosomes and spindle
fibers. Chromosomes must align perfectly
on the spindle fibers. Microtubule
filaments make the spindle fibers. The
site of interaction between the microtubule filament and chromosomes are called
kinetochores. When the interaction is
complete, Polar Ejection Force (PEF) pulls the chromosomes apart. They found this defect in interaction is
pretty common, occurring in almost 90% of cells. When it occurs in somatic cells, either the
cells die, or cancer develops. When it
occurs in gametes, there can be serious birth defects. The research shows the strength of PEF is
essential is proper cell division.
This article was really interesting
because it shows how commonly mistakes can occur during mitosis. Our bodies are made up of billions of cells,
so mitosis is very common. It is scary
to think that problems that fairly common can cause cancer in our body. It also must be concerning for couples
planning to have kids, and defects in egg or sperm cells can cause serious
birth defects. I hope the scientists
find a way to prevent such inaccuracies during mitosis.